Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Witschi, H.
Right arrow Articles by Kehrer, J. P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Witschi, H.
Right arrow Articles by Kehrer, J. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Adenoma Development in Mouse Lung Following Treatment with Possible Promoting Agents

Hanspeter Witschi

Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830

James P. Kehrer

The University of Tennessee, Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge, TN 37830

We have examined under what conditions it might be feasible to enhance the sensitivity of the mouse lung adenoma bioas-say. In mice given one single dose of urethan, the number of tumors formed can be increased 2-4 fold by repeated treatments with butylated hydroxytoluene (BHT). The minimum number of injections required to increase the number of tumors which develop is 4 and treatment may begin as late as 4 months after urethan and still be effective. BHT has no effect on tumor development in strains of mice resistant to adenoma formation or in susceptible mice treated with other carcinogens. Although it was initially thought that BHT enhances adenoma formation by stimulating type II cell proliferation in lung, new data suggest that massive cell proliferation is not necessarily a prerequisite for enhancement of tumor formation. A dose of BHT too small to produce noticeable type II cell division (50 mg/kg) enhances tumor development, whereas repeated treatment with oxygen, although stimulating cell division in lung, is without effect on tumor development. In addition, treatment of mice with BHT and SKF 525A, which prevents BHT-induced lung damage, enhances tumor formation as efficiently as does BHT alone.

International Journal of Toxicology, Vol. 1, No. 1, 171-184 (1982)
DOI: 10.3109/10915818209013139
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?