Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Pereira, M. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Pereira, M. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Mouse Skin Bioassay for Chemical Carcinogens

Michael A. Pereira

Toxicological Assessment Branch, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH 45268

The mouse skin initiation/promotion bioassay is one of the proposed bioassays of the Carcinogenesis Testing Matrix for tier II (Bull and Pereira, 1980). A review of the literature indicated that 544 chemicals and substances have been examined by application to mouse skin for carcinogenic activity. Poly-cyclic aromatic hydrocarbons, direct acting alkylating agents, and environmental samples of complex mixtures and subtractions of them that include condensates of automobile exhaust and cigarette smoke have been demonstrated to be carcinogenic by the mouse skin bioassay. Chemical classes of carcinogens that have not been demonstrated to contain initiation and carcinogens in mouse skin include azoxy, diazo, halogenated methanes, hydrazine, inorganics, steroids, and sulfonates. The mouse skin assay can be modified so mat the test substance is administered systemically i.e., oral and intraperitoneal and the promoter applied topically. This modification has the potential of increasing the number of chemical classes detected in the mouse skin initiation/promotion bioassay.

International Journal of Toxicology, Vol. 1, No. 1, 47-82 (1982)
DOI: 10.3109/10915818209013134
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?