Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Reddy, J. K.
Right arrow Articles by Yeldandi, A. V.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Reddy, J. K.
Right arrow Articles by Yeldandi, A. V.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Peroxisome Proliferation: A Biological Marker for Toxicological Evaluation

Janardan K. Reddy

Department of Pathology Northwestern University Medical School Chicago, IL 60611

M. Sambasiva Rao

Department of Pathology Northwestern University Medical School Chicago, IL 60611

Anjana V. Yeldandi

Department of Pathology Northwestern University Medical School Chicago, IL 60611

Peroxisome proliferators constitute an important group of xenobiotics with therapeutic, societal, and agricultural importance. Because these agents induce liver tumors in rodents, but fail to exert the genotoxic or mutagenic effects directly in short-term in vitro test systems, they are considered a paradigm to investigate the mechanisms of nongenotoxic hepatocarcinogenesis. A concerted cell biological, biochemical, and molecular biological approach is essential to understand the relationship of xenobiotic-induced peroxisome proliferation to the eventual development of liver tumors. It is our intent to provide insight into the mechanisms responsible for tissue specificity and species differences in the biological responses to peroxisome proliferators.

International Journal of Toxicology, Vol. 11, No. 3, 349-352 (1992)
DOI: 10.3109/10915819209141874
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?