Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Mcguire, E. J.
Right arrow Articles by De La Iglesia, F. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Mcguire, E. J.
Right arrow Articles by De La Iglesia, F. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Chemical Structure-Activity Relationships: Peroxisome Proliferation and Lipid Regulation in Rats

Edward J. Mcguire

Department of Pathology and Experimental Toxicology Parke-Davis Pharmaceutical Research Division Warner-Lambert Company Ann Arbor, MI

Robert H. Gray

Department of Pathology and Experimental Toxicology Parke-Davis Pharmaceutical Research Division Warner-Lambert Company Ann Arbor, MI

Felix A. De La Iglesia

Department of Pathology and Experimental Toxicology Parke-Davis Pharmaceutical Research Division Warner-Lambert Company Ann Arbor, MI

Studies described here address structure-activity relationships of novel hypolipidemic agents that induce peroxisome proliferation. Male rats were given equivalent doses of three well-studied fibrates, fibrate amides, and structurally dissimilar agents. Aryloxyalkanoic acids, amide analogs, and thio, benzimidazole, phenylpiperazine, and oxazole derivatives induced peroxisome proliferation and decreased plasma cholesterol and triglyceride levels. These compounds contain an acidic function or appear to be readily metabolized to a derivative with an acidic function. Substitution of this substituent with an adamantyloxy eliminated peroxisome proliferation and induced contrasting effects on the lipid profile, substantially increasing triglycerides. A direct correlation was established between hepatocellular peroxisome proliferation and plasma high-density lipoprotein (HDD-cholesterol levels.

International Journal of Toxicology, Vol. 11, No. 3, 353-361 (1992)
DOI: 10.3109/10915819209141875
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?