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International Journal of Toxicology
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Final Report on the Safety Assessment of Sodium Cocoyl Isethionate

Sodium Cocoyl Isethionate is used as a surfactant-cleansing agent in cosmetic formulations. Sodium Cocoyl Isethionate is slightly to practically nontoxic, with an oral LD50 of ≥ 4.33 g/kg for rats. Dermal application of 1.0–36.0% w/w aqueous Sodium Cocoyl Isethionate to rats for 28 days did not produce any significant toxic effects.

The ocular irritation produced by Sodium Cocoyl Isethionate was concentration dependent, ranging from a mild reaction at a test concentration of 2.5% to a primary ocular irritant at test concentrations of 49%. Sodium Cocoyl Isethionate is neither a sensitizer nor phototoxic compound.

Sodium Cocoyl Isethionate was nonmutagenic in an in vitro chromosomal aberration assay and did not produce a positive response in an S. typhimurium reverse mutation assay.

Based on the concentration of test cited in this report, it is concluded that Sodium Cocoyl Isethionate is safe for use in cosmetic formulations at 50% in rinse-off products and at 17% in leave-on products.

International Journal of Toxicology, Vol. 12, No. 5, 459-479 (1993)
DOI: 10.3109/10915819309141599
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