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Toxicity Studies of Partially Hydrolyzed Guar Gum

Sandoz Nutrition 5320 W. 23rd Street, P.O. Box 370, Minneapolis, MN 55440, U.S.A.

Sung Ik Yang

Sandoz Nutrition 5320 W. 23rd Street, P.O. Box 370, Minneapolis, MN 55440, U.S.A.

Masaru Fujiki

Sandoz Nutrition 5320 W. 23rd Street, P.O. Box 370, Minneapolis, MN 55440, U.S.A.

Mujo Kim

Sandoz Nutrition 5320 W. 23rd Street, P.O. Box 370, Minneapolis, MN 55440, U.S.A.

Takehiko Yamamoto

Sandoz Nutrition 5320 W. 23rd Street, P.O. Box 370, Minneapolis, MN 55440, U.S.A.

Norman A. Greenberg

Sandoz Nutrition 5320 W. 23rd Street, P.O. Box 370, Minneapolis, MN 55440, U.S.A.

The toxicity of partially hydrolyzed guar gum (PHGG, average molecular weight 20,000) was evaluated in a 28-day, repeated oral dosing study (gavage) in rats at doses of 0, 500, and 2,500 mg/kg/day and in Salmonella typhimurium, with and without metabolic activation. PHGG did not elicit any signs of toxicity at the doses tested. PHGG was not mutagenic.

Key Words: Partially hydrolyzed guar gum • Toxicity

International Journal of Toxicology, Vol. 13, No. 4, 273-278 (1994)
DOI: 10.3109/10915819409140599


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