This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Knight, E.V. Articles by Powers, W.J. Search for Related Content PubMed Articles by Knight, E.V. Articles by Powers, W.J. Social Bookmarking                         What's this?

Influence of Origin or Controlled Feeding On Longevity of Sprague-Dawley Rats

Drug Safety Evaluation, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, USA

D.S. Barrett

Drug Safety Evaluation, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, USA

C.M. Keenan

Drug Safety Evaluation, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, USA

J.P. Kimball

Drug Safety Evaluation, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, USA

B.H. Eitzen

Drug Safety Evaluation, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, USA

S. Bryant

Drug Safety Evaluation, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, USA

L.N. Smith

Drug Safety Evaluation, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, USA

R.J. Szot

Drug Safety Evaluation, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, USA

W.J. Powers

Drug Safety Evaluation, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, USA

Two-year studies were undertaken in Sprague-Dawley (SD) rats to assess the effects of origin, group housing, or various feeding regimens on longevity. This report describes results of in-life findings pertaining to body weight gain, food consumption, palpable masses, and preliminary analysis of clinical pathology parameters and necropsy observations. The first study compared ad libitum feeding of SD rats from the following suppliers: Charles River Labs (CRL) International Standard (IS) and Original Standard (OS), Ace Animals, Inc., and Harlan Sprague-Dawley, Inc. The second study assessed individual and group housed ad libitum feeding of Purina Certified Rodent Chow 5002 (20% crude protein), and individually housed controlled feeding of either Purina 5002 or Opti-diet (14% crude protein). The in-life phase of the third study has recently been completed. This study compared controlled (5.5 g Purina 5002 biscuit) to ad libitum (Purina 5002) feeding in CRL IS rats. In the supplier study, survival of male rats was markedly greater for CRL (IS) rats when compared to other groups. Body weight gain and food consumption were greatest in the CRL (OS) rats. Increases in cholesterol, triglycerides, urea nitrogen, and gross renal disease were observed in Harlan and Ace SD rats, while CRL rats had a higher incidence of grossly detectable pituitary masses and foci. In the feeding study, controlled feeding significantly increased the survival rate and decreased body weight gain. Single and group housed SD rats fed ad libitum had decreased T4 and markedly higher cholesterol and triglyceride values, when compared to rats fed controlled diets. Survival of IS rats fed a controlled diet was also notably higher than ad libitum-fed IS rats in the third study.

Key Words: supplier • ad libitum feeding • controlled feeding • survival

International Journal of Toxicology, Vol. 17, No. 2 Suppl, 57-78 (1998)
DOI: 10.1177/109158189801700204


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. Kemi, K. P. Keenan, C. Mccoy, C.-M. Hoe, K. A. Soper, G. C. Ballam, and M. J. Van Zwieten The Relative Protective Effects of Moderate Dietary Restriction versus Dietary Modification on Spontaneous Cardiomyopathy in Male Sprague-Dawley Rats Toxicol Pathol, March 1, 2000; 28(2): 285 - 296. [Abstract] [PDF]