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Toxicological Studies of a Representative Xerox Reprographic Toner

Center for Technology, Xerox Corporation, Webster, New York, USA

Joseph C. Wilson

Center for Technology, Xerox Corporation, Webster, New York, USA

Typical Xerox reprographic toners consist of a thermoplastic polymer as the major component, a colorant (carbon black or color pigment), and low quantities of additives such as charge control and/or lubricating agents. Another type of Xerox toner contains iron oxides and a polymer as the major components. Among all toners marketed by Xerox Corporation, the original 1075 toner (being discontinued and reformulated) was a major safety concern, because it contained approximately 2% cetylpyridinium chloride (CPC) as a charge control agent. CPC by itself is very toxic and causes severe irritation to the eye and skin. Although CPC has been used in very low concentrations in consumer products such as mouthwash, it was unknown whether a 50-fold dilution of CPC in the toner formulation would represent any safety issue. Therefore, a series of toxicological testing on the original 1075 toner was conducted. The test results indicate that the original Xerox 1075 toner was practically nontoxic following acute oral, dermal, and inhalation exposures; nonirritating to the eye; nonir-ritating/nonsensitizing to the skin; nonmutagenic in a battery of short-term assays (Ames Salmnonella/microsome assay, mouse lym-phoma assay, in vitro sister chromatid exchange assay in Chinese hamster ovarian cells, and in vitro BALB/3T3 cell transformation assay); and nonteratogenic in rats when inhaling the toner dust up to 1.2 g/m³. In addition, no mutagenic responses were observed from testing the urine or feces (by Ames test) and bone marrow (by examining micronucleus formation) of rats exposed to the toner dust at 1.3 g/m³ at the end of a subchronic inhalation study. Because all Xerox toners are alike, the toxicology of the original Xerox 1075 toner was considered a "worst-case" situation, relative to health and safety. However, it did not appear to represent any health and safety issue. The results of this study, together with the fact that no evidence of carcinogenicity was found in the Xerox chronic inhalation study on toner, indicate that Xerox toners are not safety hazards, with respect to the end points indicated in this report.

International Journal of Toxicology, Vol. 18, No. 1, 23-34 (1999)
DOI: 10.1080/109158199225774


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