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International Journal of Toxicology
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Animal Models Used in Identifying Gender-Related Differences

Bishop B. Curry, III

Laboratory Animal Resources, Charles River Laboratories Discovery and Development Services, Worcester, Massachusetts, USA

There is general agreement in the scientific community on the need to identify appropriate animal models that can be used to screen for gender-based differences. At the same time, there is a growing expectation for data from these models to mimic or be more predictive of the human experience. The species in this review will include nonhuman primates, rats, mice, rabbits, swine, hamsters, gerbils, quail, and fish. Although some of the models are unique, the gender-related differences, in most instances, may be correlated with man, due to the conservation of biological systems across species.

Key Words: Animal Models • Gender Difference • Mice • Monkey • Rabbit • Rat

International Journal of Toxicology, Vol. 20, No. 3, 153-160 (2001)
DOI: 10.1080/109158101317097737
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[Abstract] [PDF]