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Changes in Cross-Fostered Sprague-Dawley Rat Litters Exposed to Perchlorate

Man Tech Environmental Technology, Inc., Air Force Research Laboratory, Human Effectiveness Directorate, Wright-Patterson Air Force Base, Ohio, USA

Kyung O. Yu

Air Force Research Laboratory, Human Effectiveness Directorate, Wright-Patterson Air Force Base, Ohio, USA

Latha Narayanan

GEO-Centers, Inc., Air Force Research Laboratory, Human Effectiveness Directorate, Wright-Patterson Air Force Base, Ohio, USA

David R. Mattie

Air Force Research Laboratory, Human Effectiveness Directorate, Wright-Patterson Air Force Base, Ohio, USA

Jeffrey W. Fisher

The University of Georgia, Department of Environmental Health Science, Athens, Georgia, USA

Ammonium perchlorate is used as an oxidizer in rocket fuel. It has become a groundwater contaminant, dissociating to ammonium cation and perchlorate anion. The perchlorate ion competes with iodide for uptake into the thyroid, reducing thyroid hormone production. Pregnant Sprague-Dawley rats were given either untreated or perchlorate (1 mg/kg-day) treated drinking water beginning on gestation day 2. One set of control and exposed dams was sacrificed on gestation day 20. The litters from the second set of control and exposed dams were crossed immediately after parturition and were sacrificed at postnatal day 10. Dam serum and thyroid, pooled fetal sera, and male and female pup sera were collected and analyzed for perchlorate, thyroid-stimulating hormone (TSH), triiodothyronine (T₃), and thyroxine (T₄). Control pups receiving perchlorate through lactation had serum levels at postnatal day 10 of 0.54 µg/ml and 0.56 µg/ml for male and female pups, respectively, whereas exposed fetuses had serum perchlorate levels of 0.38 ± 0.04 µg/ml. Female pups receiving perchlorate lactationally had significantly lower levels of serum T₄ than control pups and prenatally exposed pups. Serum T₄ levels in male pups were not affected by perchlorate. Serum thyroid hormone levels from gestational perchlorate exposure were restored to control values by postnatal day 10. In utero perchlorate-exposure decreased serum T₄ levels in the fetus. Gestational studies in conjunction with a crossfostering study design helped discern thyroid hormonal changes caused by perchlorate exposure during the perinatal period.

Key Words: Cross-Foster • In Utero • Lactational • Perchlorate • Rat • Thyroid Hormone

International Journal of Toxicology, Vol. 22, No. 2, 87-94 (2003)
DOI: 10.1080/10915810305088


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