Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Toxicology
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by York, R. G.
Right arrow Articles by Dodd, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by York, R. G.
Right arrow Articles by Dodd, D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Articles

A Rat Neurodevelopmental Evaluation of Offspring, Including Evaluation of Adult and Neonatal Thyroid, from Mothers Treated with Ammonium Perchlorate in Drinking Water

Raymond G. York1
John Barnett, Jr.1
W. Ray Brown2
Robert H. Garman3
David R. Mattie4
Darol Dodd5

1 Argus Division-DDS, Charles River Laboratories, Inc., Horsham, Pennsylvania, USA
2 Research Pathology Services, Inc., New Britain, Pennsylvania, USA
3 Consultants in Veterinary Pathology, Inc., Murrysville, Pennsylvania, USA
4 AFRL/HEPB, Wright Patterson Air Force Base, Ohio, USA
5 ManTech Environmental Technology, Inc., Dayton, Ohio, USA

Correspondence: Address correspondence to Raymond G. York, PhD, Argus Division, DDS, Charles River Laboratories, 905 Sheehy Drive, Building A, Horsham, PA 19044, USA. E-mail:raymond.york{at}argus.criver.com

The purpose of this study was to evaluate the potential neurodevelopmental toxicity of perchlorate exposure during gestation and the first 10 days of lactation. Mated Sprague-Dawley rats (25/exposure group) were given continual access to 0, 0.1, 1.0, 3.0, or 10.0 mg/kg-day ammonium perchlorate (AP) in drinking water, starting gestation day 0 (mating) through lactation day 10 (DL 10). One pup/sex/litter/exposure group was assigned to (1) juvenile brain weights, morphometry, and neuropathology; (2) passive avoidance and watermaze testing; (3) motor activity and auditory startle habituation; and (4) adult regional brain weights, morphometry, and neuropathology. AP had no effect on body weights, feed consumption, clinical observations, or sexual maturation of pups at exposures as high as 10.0 mg/kg-day. There were no behavioral effects in the offspring exposed as high as 10.0 mg/kg-day as evaluated by passive avoidance, swimming watermaze, motor activity, and auditory startle. Increases in hypertrophy and hyperplasia of the thyroid follicular epithelium and a decrease in the thyroid follicle size were observed in culled male pups in the 10.0 mg/kg-day group on DL 5. The exposure level for effects on triiodothyroxine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) levels for pups were 0.1, 1.0, and 3.0 mg/kg-day, respectively. There was an apparent increase in the thickness of the corpus callosum of the 10 mg/kg-day group pups on DL 12. The no-observed-adverse-effect level (NOAEL) for maternal toxicity was greater than 10.0 mg/kg-day. Based on the thyroid morphometric and histopathologic findings, the NOAEL for pup toxicity was 0.1 mg/kg-day.

Key Words: Developmental Neurotoxicity • Maternal Hypothyroidism • Perchlorate • Rat • Thyroid

International Journal of Toxicology, Vol. 23, No. 3, 191-214 (2004)
DOI: 10.1080/10915810490475835
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Toxicol PatholHome page
M. A. Khan, S. E. Fenton, A. E. Swank, S. D. Hester, A. Williams, and D. C. Wolf
A Mixture of Ammonium Perchlorate and Sodium Chlorate Enhances Alterations of the Pitutary-Thyroid Axis Caused by the Individual Chemicals in Adult Male F344 Rats
Toxicol Pathol, December 1, 2005; 33(7): 776 - 783.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
R. G. York, E. Lewis, W. R. Brown, M. F. Girard, D. R. Mattie, K. A. Funk, and J. S. Strawson
Refining the Effects Observed in a Developmental Neurobehavioral Study of Ammonium Perchlorate Administered Orally in Drinking Water to Rats. I. Thyroid and Reproductive Effects
International Journal of Toxicology, November 1, 2005; 24(6): 403 - 418.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
R. G. York, J. Barnett Jr., M. F. Girard, D. R. Mattie, M. V. K. Bekkedal, R. H. Garman, and J. S. Strawson
Refining the Effects Observed in a Developmental Neurobehavioral Study of Ammonium Perchlorate Administered Orally in Drinking Water to Rats. II. Behavioral and Neurodevelopment Effects
International Journal of Toxicology, November 1, 2005; 24(6): 451 - 467.
[Abstract] [Full Text] [PDF]