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International Journal of Toxicology
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Individual Reference Intervals of Hematological and Serum Biochemical Parameters in Cynomolgus Monkeys

Tadashi Koga

Shin Nippon Biomedical Laboratories, Ltd. (SNBL), Kagoshima, Japan

Koji Kanefuji

The Institute of Statistical Mathematics, Tokyo, Japan

Kazuhiro Nakama

Shin Nippon Biomedical Laboratories, Ltd. (SNBL), Kagoshima, Japan

Correspondence: Address correspondence to Tadashi Koga, Shin Nippon Biomedical Laboratories, 2438 Miyanoura, Kagoshima, 891-1394, Japan. E-mail:koga-tadashi{at}snbl.co.jp

Cynomolgus monkeys, one of a number of primates phylogenetically close to humans, are commonly used in animal studies. The purpose of this study was to assess biological variations in hematological and serum biochemical parameters in cynomolgus monkeys. Summary statistics and reference intervals were calculated using data from 95 male and 95 female Chinese-bred cynomolgus monkeys aged 3 to 7 years showing no abnormalities during the breeding period. Within- and between-animal variations were estimated using a random-effect analysis of variance (ANOVA), then, a simple method that applies prior information was proposed to estimate individual reference intervals. Parameters including MCV, MCH, PT, ALP, total cholesterol, and creatinine appeared to show a large between-animal variation; thus, it is considered that individual reference intervals for these parameters would be relatively small in comparison with overall reference intervals.

Key Words: Biochemistry • Cynomolgus Monkeys • Hematology • Macaca fascicularis • Normal Ranges • Reference Intervals

International Journal of Toxicology, Vol. 24, No. 5, 377-385 (2005)
DOI: 10.1080/10915810500208058
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