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International Journal of Toxicology
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Articles

Effect of Clofibric Acid on Desmin and Vimentin Contents in Rat Myocardiocytes

Adriana Sampayo-Reyes
Antonio Narro-Juárez

División de Farmacología y Toxicología del Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México

Salvador Saíd-Fernández
Héctor G. Lozano-Garza
Javier Vargas-Villarreal
Benito D. Mata-Cárdenas

División de Biología Celular y Molecular del Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México

Antonio Morales-Aguilera
María Teresa González-Garza

Escuela de Medicina del Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Nuevo León, México

Elva I. Cortés-Gutiérrez
Ricardo M. Cerda-Flores

División de Genética del Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México

Herminia G. Martínez-Rodríguez

Unidad de Laboratorios de Ingeniería y Expresión Genética, Departamento de Bioquímica de la Facultad de Medicina de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México

Correspondence: Address correspondence to Adriana Sampayo-Reyes, PhD, División de Farmacología y Toxicología, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social (IMSS), Monterrey, Nuevo León, México, 2 de abril y San Luis Potosí, Colonia Independencia, Monterrey, Nuevo León, México, CP 64720, Administración de Correo No. 4. Apartado postal 020-E. E-mail:adriana.sampayo{at}biomedicas.net

The aim of this experimental study was to analyze in vitro effects of clofibric acid on vimentin and desmin contents in rat myocardiocytes, which was carried out in primary myocardiocyte cells that were treated only with clofibric acid at 0.1 mM. The measurement of vimentin and desmin were done by Western blotting and densitometry. This study showed that myocardiocytes exposed to clofibric acid exhibit a 26.3% decrease in vimentin and a 42.1% decrease in desmin. Considering the role that these intermediate filaments play in the anchorage and cellular organization of myocardiocytes, the decrease of desmin and vimentin observed in cells treated with clofibric acid may be partially responsible for the adverse effects observed in patients. In conclusion, the alteration of cytoskeletal proteins may be a cause of cardiopathy in patients treated with these compounds.

Key Words: Clofibrate • Clofibric Acid • Desmin • Myocardiocytes • Vimentin

International Journal of Toxicology, Vol. 25, No. 5, 403-408 (2006)
DOI: 10.1080/10915810600846989
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