This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Griffiths, J. C. Articles by Power, R. Search for Related Content PubMed PubMed Citation Articles by Griffiths, J. C. Articles by Power, R. Social Bookmarking                         What's this?

Genotoxicity Studies on Sel-Plex^®, a Standardized, Registered High-Selenium Yeast

Burdock Group, Vero Beach, Florida, USA

Ronan Power

North American BioSciences Center, Alltech Inc., Nicholasville, Kentucky, USA

Correspondence: Address correspondence to James C. Griffiths, Director of Toxicology, Burdock Group, 2001 9th Avenue, Suite 301, Vero Beach, FL 32960, USA. E-mail:jgriffiths{at}burdockgroup.com

Selenium, recognized as an essential nutrient for human health, is a component of proteins and enzymes required for various biological functions and is currently being used as a feed supplement for livestock in geographical areas that are naturally low in selenium. Selenium is structurally similar to sulfur, replacing the sulfur atom in stoichiometric amounts and thus functions through an association with proteins, termed selenoproteins. In geographic areas low in selenium, there is the potential for animals (including humans) to become selenium deficient and this potential deficiency can be remedied by consumption of exogenous selenium, including selenium-enriched yeast (Saccharomyces cerevisiae) that contains high levels of organic selenium (e.g., selenized yeast). A unique, standardized, registered high selenium food-grade baker’s yeast (S. cerevisiae; Sel-Plex^®), was tested in the following battery of Genotoxicity assays; (1) a bacterial reverse mutation test (Ames test); (2) an in vitro mammalian chromosome aberration test; and (3) a mouse micronucleus test. Under the conditions of this assay, Sel-Plex^® showed no evidence of mutagenic activity in Salmonella typhimurium, in the bacterial reverse mutation test. Sel-Plex^® did not induce significant chromosomal aberrations in cultured human lymphocytes in the in vitro mammalian chromosome aberration test. Sel-Plex^® did not statistically increase the frequency or proportion of micronucleated immature erythrocytes in the mouse micronucleus test. Thus, from the studies presented here, the authors conclude that Sel-Plex^® is nongenotoxic.

Key Words: Genotoxicity • Saccharomyces cerevisiae • Selenium • Yeast

International Journal of Toxicology, Vol. 25, No. 6, 477-485 (2006)
DOI: 10.1080/10915810600959667


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?