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International Journal of Toxicology
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Article

Potential Side Effects of Dendritic Cells Pulsed with Allogenic Melanoma Cell Lysate in Mice

Shin-Young Park
Woo Hyuck Choi
Yong Bum Kim
Chang Su Ha

Korea Institute of Toxicology, Daejeon, Korea

Hyunah Lee

Cancer Center, Samsung Medical Center, Seoul, Korea

Young-Do Kwon
Ok-Mi Choi
Young-Joon Lee

Medipost Biomedical Research Institute, Seoul, Korea

Woo Suk Koh

Korea Institute of Toxicology, Daejeon, Korea

Correspondence: Address correspondence to Dr. Woo Suk Koh, Korea Institute of Toxicology, P.O. Box 123, 100 Jang-dong, Yusung-gu, Daejeon 305-600, Korea. E-mail:wskoh{at}kitox.re.kr

An attempt has been made to investigate the toxicity of cancer immunotherapy based on the dendritic cells pulsed with lysate of allogenic melanoma cell, DM401. Dendritic cells pulsed with lysate of clone M3 were subcutaneously administered once a week eight times to C57BL/6 mice at 0, 2.5, 5, and 10 x 107 cells/kg. No changes attributable to the administration were observed in clinical signs and food and water consumption. The administration induced slight increases in body weights, white blood cells, total protein, total cholesterol, triglyceride, phospholipids, and absolute spleen weights, but a slight decrease in albumin/globulin ratio. Microscopic examinations revealed the infiltration of inflammatory cells in the lung, mainly in the pulmonary arteriole, in which the tunica media thickened, and in the pulmonary alveoli and alveolar space. Thickened tunica media of pulmonary arteriole was observed in both males and females at all selected doses. In addition, the subcutis at the test substance-application site showed inflammation and fibrosis. In conclusion, lung is a target organ of DM401, and most of the changes including the findings in lung are considered as the immunomodulatory functions of dendritic cells.

Key Words: Dendritic Cells • Immunotherapy • Lung • Melanoma • Mice

International Journal of Toxicology, Vol. 26, No. 1, 33-40 (2007)
DOI: 10.1080/10915810601118164
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