Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Toxicology
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow An erratum has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Related articles in International Journal of Toxicology
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kumar, R. V.
Right arrow Articles by Devaki, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kumar, R. V.
Right arrow Articles by Devaki, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Article

Inhibitory Effects of Histone Deacetylase Inhibitor Depsipeptide on Benzo(a)pyrene- and Cyclophosphamide-Induced Genotoxicity in Swiss Albino Mice

Radhakrishnan Vinodh Kumar

Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India

Park Chung Mu

School of Food and Life Science, Inje University, Kimhae, Korea

Vilwanathan Ravikumar

College of Oriental Medicine, Kyung-Hee University, Seoul, Korea

Thiruvengadam Devaki

Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India

Correspondence: Address correspondence to Dr. (Mrs.) T. Devaki, MSc, MPhil, PhD, Professor, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India. E-mail:devakit{at}yahoo.co.uk

Depsipeptide (FK228 or FR901228) was evaluated in the mouse bone marrow micronucleus test for its possible protective effect against chromosomal damage induced by benzo(a)pyrene and cyclophosphamide. Three doses of depsipeptide (0.5, 1, and 1.5 mg/kg body weight) were given intravenously to mice for 7 consecutive days prior to administration of genotoxins under investigation. All the three doses of depsipeptide were effective in exerting a protective effect against both benzo(a)pyrene and cyclophosamide. A significant suppression (34.9% to 67.5%) in the micronuclei formation induced by benzo(a)pyrene and (25.7% to 71.5%) cyclophosphamide was observed following intravenous administration of depsipeptide at doses of 0.5, 1, and 1.5mg/kg in Swiss albino mice.

Key Words: Benzo(a)pyrene • Cyclophosphamide • Depsipeptide • FK228 • Genotoxicity • Micronucleus Test

International Journal of Toxicology, Vol. 26, No. 1, 47-50 (2007)
DOI: 10.1080/10915810601120111
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in International Journal of Toxicology:

Erratum

International Journal of Toxicology 2007 26: 277. [Full Text]