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International Journal of Toxicology
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Articles

Detrimental Effects of N-Acetylcysteine Plus Desferoxamine Combination in an Experimental Nephrotic Syndrome Model

F. Bulucu

Department of Internal Medicine, Gülhane Military Medical Academy, Ankara, Turkey

C. Oktenli

Division of Internal Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey

L. Kenar

Department of Biochemistry, Gülhane Military Medical Academy, Ankara, Turkey

B. Koc
R. Ocal
N. Karadurmus
V. Inal
L. Yamanel

Department of Internal Medicine, Gülhane Military Medical Academy, Ankara, Turkey

Y. S. Sanisoglu

Department of Monitoring and Evaluation, Turkish Ministry of Health, Ankara, Turkey

A. Aydin

Department of Pharmaceutical Sciences, Gülhane Military Medical Academy, Ankara, Turkey

Correspondence: Address correspondence to Fatih Bulucu, MD, Department of Internal Medicine, Gülhane Military Medical Academy, TR-06018 Etlik Ankara, Turkey. E-mail:fbulucu{at}gata.edu.tr;coktenli{at}yahoo.com

The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) and desferoxamine (DFO) administered alone or in combination together in rats with doxorubicin (DOX)-induced nephrotic syndrome, by monitoring oxidative stress parameters and trace elements in renal tissue and erythrocytes. Fifty-four male Sprague-Dawley rats were included the study. Equal volume of isotonic saline was injected to control rats. After DOX administration, the animals were divided into four experimental groups: (a) rats given only DOX; (b) rats treated with NAC; (c) rats treated with DFO; (d) rats treated with NAC plus DFO. The combination of N-acetylcysteine and DFO has no beneficial effect on reducing proteinuria in experimentally nephrotic rats, although both of these agents ameliorate the condition when administered separately. It seems likely that detrimental effects of NAC plus DFO could be secondary to its effects on erythrocyte selenium levels demonstrated here. Consequently, the results may propose caution to the use of antioxidant therapeutic strategies such as NAC plus DFO against nephropathy.

Key Words: Desferoxamine • Doxorubicin • N-Acetylcysteine • Nephrotic Syndrome

International Journal of Toxicology, Vol. 26, No. 6, 525-532 (2007)
DOI: 10.1080/10915810701707403
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