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International Journal of Toxicology
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Mechanism and Treatment of Sulfide-Induced Coma: A Rat Model

A. F. Almeida

Department of Public Health Sciences, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada TG6 2G3

P. N. Nation

Health Sciences Laboratory Animal Services, University of Alberta, Edmonton, Alberta, Canada T6G 2H7

T. L. Guidotti

Department of Environmental and Occupational Health, School of Public Health & Health Services, The George Washington University, Washington DC 20052

Correspondence: Address correspondence to Tee L. Guidotti, Department of Environmental and Occupational Health, George Washington University School of Public Health and Health Services, 2100 K Street, NW, Suite 203, Washington DC 20052 USA. E-mail:eohtlg{at}gwumc.edu

Sodium hydrosulfide and dimethylsulfide duplicate the effects of hydrogen sulfide in causing coma in Sprague-Dawley rats and are additive for lethality. Nitrite, pyruvate and dithiothreitol had no significant effect on coma or lethality but bicarbonate with and without glucose reduced duration of coma. This finding suggests an antidotal treatment.

Key Words: Antidotes • Coma • Dimethyl sulfide • Dithiothreitol • Hydrogen sulfide • Sodium hydrosulfide

International Journal of Toxicology, Vol. 27, No. 3, 287-293 (2008)
DOI: 10.1080/10915810802210166
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