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International Journal of Toxicology
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Articles

Effects of Atrazine and Fenoxaprop-Ethyl on Capacitation and the Acrosomal Reaction in Boar Sperm

Ramiro Maravilla-Galván
Reyna Fierro
Humberto González-Márquez
Sandra Gómez-Arroyo
Irma Jiménez
Miguel Betancourt

From the Doctorado en Ciencias Biológicas, Universidad Autónoma Metropolitana, México; Ciencias de la Salud, Universidad Autónoma Metropolitana–Iztapalapa, México; Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma Metropolitana, México; and Ciencias de la Salud, Universidad Autónoma Metropolitana–Iztapalapa, México

Correspondence: Please address correspondence to Reyna Fierro, Universidad Autónoma Metropolitana–Iztapalapa, Depto de Ciencias de la Salud, San Rafael Atlixco 186, Iztapalapa, D.F., C.P. 09340, México; e-mail:reyna{at}xanum.uam.mx.

Atrazine is a herbicide of the chloro-s-triazine family. It inhibits photosynthesis in plants and is an endocrine disruptor, but its effects on human health are controversial. Fenoxaprop-ethyl, an aryloxy phenoxyalkanoic acid herbicide, inhibits the biosynthesis of fatty acids and provokes depolarization of membranes. The aim of this study is to evaluate the in vitro effects of both herbicides on capacitation, spontaneous acrosome reaction (SAR) and progesterone-induced acrosome reaction (PIAR) in boar sperm. Sperm capacitation is done in TALP-HEPES media for 4 hours. Capacitation and SAR are evaluated immediately; PIAR, 30 minutes later. LC50 for fenoxaprop-ethyl is 60 mM and 40 mM for atrazine. Fenoxaprop-ethyl induces capacitation at 60 mM and SAR at all concentrations, also increases significantly PIAR. Atrazine decreased capacitation whereas increase significantly SAR and PIAR at all concentrations. It seems that fenoxaprop-ethyl and atrazine accelerate the capacitation and the acrosomal reaction, possibly via plasma membrane destabilization.

Key Words: acrosome reaction • atrazine • boar sperm • capacitation • fenoxaprop-ethyl

International Journal of Toxicology, Vol. 28, No. 1, 24-32 (2009)
DOI: 10.1177/1091581809333138
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Erratum

International Journal of Toxicology 2009 28: 334. [Full Text]