Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Schmidt, R. R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Schmidt, R. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Altered Development of Immunocompetence Following Prenatal or Combined Prenatal-Postnatal Insult: A Timely Review

R. R. Schmidt

The Daniel Baugh Institute of Anatomy Jefferson Medical College 1020 Locust Street Philadelphia, PA 19107

There is an unequal distribution of interest between assessment of immunocompetence at the adult level following the administration of various agents/protocols and evaluation of immunocompetence postnatally subsequent to prenatal insult. This paper reviews the effects of dietary manipulation, selected pharmaceuticals, and certain environmental agents on the functional status of the postnatal immune system after in utero exposure to these agents and protocols. These data are discussed in light of what has also been observed for adult exposure to the same or similar experimental design. A discussion of congenital disorders of immunocompetence is also provided. Alteration in the development of postnatal immunocompetence following prenatal insult may manifest itself in several ways, some of which may reflect a permanent defect while others may be of a transient nature. In either instance, however, it behooves scientists in all arenas to (1) determine the precise nature and magnitude of such developmentally related immunologic deficits and (2) focus on the selection and standardization of the most relevant procedures to be employed in the assessment of immunocompetence.

International Journal of Toxicology, Vol. 3, No. 1, 57-72 (1984)
DOI: 10.3109/10915818409009073
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?