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A Selected Review of Risk Models: One Hit, Multihit, Multistage, Probit, Weibull, and Pharmacokinetic

Department of Health Science, California State University, and Division Risk Analyses and Quality Assurance, Bureau of Business Services and Research, School of Business Administration and Economics, California State University, Northridge, California.

T. Wedel

Department of Management Science, School of Business Administration and Economics, California State University, Northridge, California.

This paper provides some of the underlying mathematical derivations for the one-hit, multihit, multistage, Weibull, and pharmacokinetic risk models. Our purposes are to remove for the nonmathematician some of the mystery as to the derivation of the formulas for each particular risk model and to discuss some of the assumptions contained in the risk models. Confidence limits and maximum likelihood estimates of the model parameters are not discussed, since they are not pertinent to our objectives. Rai and Van Ryzin⁽¹⁾ have outlined these procedures in sufficient detail.

International Journal of Toxicology, Vol. 4, No. 4, 271-278 (1985)
DOI: 10.3109/10915818509078679


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