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International Journal of Toxicology
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Pattern of Response of Intact Drosophila to Known Teratogens

R.L. Schuler

Research Biologist National Institute for Occupational Safety and Health Mail Stop: C-23 4676 Columbia Parkway Cincinnati, OH 45226

M.A. Radike

Research Biologist National Institute for Occupational Safety and Health Mail Stop: C-23 4676 Columbia Parkway Cincinnati, OH 45226

B.D. Hardin

Research Biologist National Institute for Occupational Safety and Health Mail Stop: C-23 4676 Columbia Parkway Cincinnati, OH 45226

R.W. Niemeier

Research Biologist National Institute for Occupational Safety and Health Mail Stop: C-23 4676 Columbia Parkway Cincinnati, OH 45226

Drosophila, as the test organism, was used to assess 17 chemicals. The teratogenic potential of 15 of these chemicals is well established from animal studies or human epidemiology. The test involves examination of adult flies following treatment during larval stages of development. Flies are examined for abnormal external morphology. The incidence of abnormalities in treated and control populations is compared using the Chi-square test. All 17 chemicals were active to varying degrees in the test system. Most chemicals produced a unique response yielding individual patterns of abnormalities. These results suggest that Drosophila may have the potential to become a valuable teratogen screen, but further, more rigorous examination–particularly with nonteratogens–is required.

International Journal of Toxicology, Vol. 4, No. 4, 291-303 (1985)
DOI: 10.3109/10915818509078681
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