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Lack of Promoting Effect of Sodium Chlorate and Potassium Chlorate in Two-Stage Rat Renal Carcinogenesis

Division of Pathology National Institute of Hygienic Sciences 1–18–1 Kamiyooga Setagaya-ku, Tokyo 158, Japan

T. Imazawa

Division of Pathology National Institute of Hygienic Sciences 1–18–1 Kamiyooga Setagaya-ku, Tokyo 158, Japan

M. Matsushima

Division of Pathology National Institute of Hygienic Sciences 1–18–1 Kamiyooga Setagaya-ku, Tokyo 158, Japan

N. Takamura

Division of Pathology National Institute of Hygienic Sciences 1–18–1 Kamiyooga Setagaya-ku, Tokyo 158, Japan

Y. Hayashi

Division of Pathology National Institute of Hygienic Sciences 1–18–1 Kamiyooga Setagaya-ku, Tokyo 158, Japan

Sodium chlorate (NaClO₃) and potassium chlorate (KClO₃), which are byproducts of water disinfection with chlorine dioxide (ClO₂), were tested for potential promoting effect in two-stage rat renal carcinogenesis. Three groups of 15 male F344 rats each were given N-ethyl-N-hydroxyethylnitrosamine (EHEN) at the level of 0.05% for the first 2 weeks during the initiation phase. Thereafter, the rats were treated orally for 25 weeks with NaClO₃ (1%), KClO₃ (1%), or distilled water (DW). Three other groups (controls) were treated similarly, except that DW was given in the initiation phase. All animals survived for the duration of the experiment. Renal neoplastic lesions were classified histologically as dysplastic foci (DF) and renal cell tumors (RCT). The number of these lesions per unit area, in six sections from each kidney, was determined microscopically. There were no statistically significant differences in the incidences and in the mean number of DF and RCT of the kidney between compound-and DW-treated rats initiated with EHEN. It is concluded that NaClO₃ and KClO₃ show no promoting effect in rat renal carcinogenesis under the conditions of this study.

International Journal of Toxicology, Vol. 4, No. 6, 331-337 (1985)
DOI: 10.3109/10915818509078696


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