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Effect of Dietary Selenite on Hepatic Organic Solvent-Soluble Lipofuscin Pigments

148 Food Science and Nutrition University of Minnesota 1334 Eckles Avenue St. Paul, MN 55108

B.Z. Menken

148 Food Science and Nutrition University of Minnesota 1334 Eckles Avenue St. Paul, MN 55108

Supplementation of selenium as sodium selenite results in an increase in hepatic organic solvent-soluble lipofuscin pigments, the metabolic end products of lipid peroxidation. Weanling mice fed a basal diet containing 0.05 ppm selenium had a significant increase in hepatic organic solvent-soluble lipofuscin pigments and glutathione peroxidase activity following supplementation of an additional 0.1 ppm selenium as sodium selenite from 5 to 9 months of age. Normal levels of vitamin E (30 mg/kg) were insufficient to protect against the oxidative effect of this increased dose of selenite. However, 10 times the normal level of vitamin E markedly suppressed this oxidative effect.

International Journal of Toxicology, Vol. 5, No. 1, 79-85 (1986)
DOI: 10.3109/10915818609140738


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