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International Journal of Toxicology
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A Possible Relationship Between Toxicity and Carcinogenicity

L. Zeise

Harvard University Jefferson 266 Cambridge, MA 02138

E. A.C. Crouch

Harvard University Jefferson 266 Cambridge, MA 02138

R. Wilson

Harvard University Jefferson 266 Cambridge, MA 02138

Carcinogenic response is compared to noncarcinogenic toxicity in that group of chemicals tested by the National Cancer Institute (NCI) and National Toxicology Program (NTP) between 1976 and 1982 and reported in the Carcinogenesis Technical Report Series. A positive finding of carcinogenicity in the bioassay is correlated with the degree of noncarcinogenic chronic toxicity of the dose applied. Comparisons of acute toxicity (LD50) with carcinogenic potency show that they are correlated, but the correlation may in part be an artifact, since doses used in the NCI/NTP carcinogenesis bioassays are toxic and because reliable measures of potency can only be derived for positive carcinogenic responses. The high correlations for certain classes of chemicals and the relationship of chronic toxicity to positive carcinogenic finding suggest that these relationships are more than spurious. Since toxicities in different species are highly correlated, these findings imply that carcinogenicities in different species are also correlated.

International Journal of Toxicology, Vol. 5, No. 2, 137-151 (1986)
DOI: 10.3109/10915818609141018
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