Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Mosher, A. H.
Right arrow Articles by Kircher, C. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Mosher, A. H.
Right arrow Articles by Kircher, C. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Proliferative Lesions of the Adrenal Medulla in Rats Treated with Zomepirac Sodium

A. H. Mosher, V.M.D., Ph.D.

Director, Pathology McNeil Pharmaceutical Spring House, PA 19477

C. H. Kircher

Director, Pathology McNeil Pharmaceutical Spring House, PA 19477

Two 24-month oral (gavage) carcinogenicity studies with zomepirac sodium were conducted in Wistar rats. Adrenal medullary proliferative lesions (focal hyperplasia and benign medullary tumors) were increased in male rats. The morphological character and biological behavior of the adrenal medullary proliferative lesions were benign and had no apparent affect on mortality. Zomepirac sodium can be added to a list of chemically and pharmacologically diverse group of substances that have been associated with increased incidences of adrenal medullary proliferative lesions in the aged rat.

International Journal of Toxicology, Vol. 7, No. 1, 83-93 (1988)
DOI: 10.3109/10915818809078704
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?