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International Journal of Toxicology
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Effects of Simultaneous Dietary Exposure to 2,2',4,4',5,5'-Hexabromobiphenyl and 3,3',4,4',5,5'-Hexachlorobiphenyl on Hepatic Tumor Promotion in Rats

M. G. Evans

Harvard Medical School New England Regional Primate Research Center One Pine Hill Drive Southborough, Massachusetts 01772

S. D. Sleight

Harvard Medical School New England Regional Primate Research Center One Pine Hill Drive Southborough, Massachusetts 01772

Female Sprague-Dawley rats were partially hepatectomized, initiated with diethylnitrosamine (DEN), and fed diets containing 2,2',4,4',5,5'-hexabromobiphenyl (245-HBB), 3,3',4,4',5,5'-hexachlorobiphenyl (345-HCB), or combinations of 245-HBB and 345-HCB to determine the tumor-promoting ability of these compounds in a two-stage (initiation/promotion) hepatocar-cinogenesis system. Tumor-promoting ability was assessed by measuring hepatic foci positive for gamma glutamyl transpeptidase (GGT) activity. Concentrations of 10 or 100 mg 245-HBB/kg of diet caused significantly increased numbers of GGT-positive hepatic foci. When 245-HBB and 345-HCB were fed simultaneously, an additive effect on tumor-promoting ability was observed at dietary concentrations of 10 mg/kg 245-HBB and 0.1 mg/kg 345-HCB. However, an inhibitory effect on tumor promotion occurred when dietary concentrations of 100 mg/kg 245-HBB and 1.0 mg/kg 345-HCB were fed simultaneously. These results suggest that the tumor-promoting ability of simultaneous exposure to 245-HBB and 345-HCB can be additive or inhibitory depending upon the concentration of each congener in the diet.

International Journal of Toxicology, Vol. 8, No. 6, 1201-1206 (1989)
DOI: 10.3109/10915818909018078
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